Wholesale MOTS-c Peptide API

What Is MOTS-c?

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded within the mitochondrial genome — specifically within the small ribosomal RNA gene MT-RNR1. First described by Dr. Pinchas Cohen and colleagues at USC in 2015, MOTS-c represents a new class of mitochondria-derived peptides (MDPs) that function as systemic metabolic regulators. MOTS-c acts primarily through AMPK activation, promoting glucose uptake in skeletal muscle independent of insulin signaling, enhancing mitochondrial biogenesis, suppressing lipogenesis, and reducing oxidative stress. Studies in aged mice show that MOTS-c administration reverses age-related insulin resistance, extends exercise capacity, and extends median lifespan — establishing it as one of the most compelling longevity peptides under investigation.

Licensed longevity clinics and metabolic health practitioners sourcing MOTS-c wholesale API require highly purified material with verified sequence identity given the peptide's small size (2174 Da) and the potential for truncated synthesis artifacts. Wholesale Peptide Distributors produces MOTS-c in ISO 5 cGMP-aligned cleanrooms from raw materials sourced from FDA green list manufacturers. Each production lot undergoes HPLC purity verification (≥98%), mass spectrometry sequence confirmation of the full 16-amino acid sequence (MRWQEMGYIFYPRKLR), endotoxin testing (<1 EU/mg), and residual solvent analysis. Full lot CoA packages are available to all approved wholesale accounts.

MOTS-c is among the higher-cost specialty peptides in the longevity category, reflecting the complexity of synthesis and the precision required for 16-amino acid peptide production. Wholesale Peptide Distributors offers competitive pricing at 5mg, 10mg, 50mg, and 100mg+ bulk quantities for clinics running metabolic optimization and anti-aging protocols. Given the research-stage nature of MOTS-c clinical application, we recommend all accounts review available literature and consult with their medical director regarding appropriate use protocols.

As longevity medicine continues to evolve from a niche specialty to mainstream clinical practice, mitochondria-targeted interventions like MOTS-c represent the frontier of peptide-based anti-aging therapy. Wholesale Peptide Distributors keeps current inventory of MOTS-c to support practices at the cutting edge of longevity medicine. Apply for a wholesale account to access pricing, availability, and documentation for your MOTS-c supply program.

Wholesale MOTS-c Ordering Details